[Treatment of Paget's disease of bone].
نویسندگان
چکیده
A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget's disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological and thermographic responses are discussed.
منابع مشابه
Quantification and comparison of bone-specific alkaline phosphatase with two methods in normal and paget’s specimens
Background: Bone-specific alkaline phosphatase (BAP) is synthesized by the osteoblasts and is presumed to be involved in the calcification of bone matrix, though its precise role in the formation process is unknown. The aim of the present study was to measure the BAP activity in Paget's and normal specimens by two different techniques. Methods: Total ALP (TAP) as well as BAP activity-measuring ...
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in the treatment of Paget's bone disease. Lancet 1971 ;i: 1 139-43. 5 Smith R, Russell RGG, Bishop MC, Woods CG, Bishop M. Paget's disease of bone. Experience with a diphosphonate (disodium etidronate) in treatment. QJ7Med 1972;42:235-56. 6 Douglas DL, Duckworth T, Kanis JA, Jefferson AA, Martin TJ, Russell RGG. Spinal cord dysfunction in Paget's disease of bone. Has medical treatment a vascula...
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INTRODUCTION Paget's disease of the bone is characterized by focal abnormalities of increased bone turnover affecting one or more sites throughout the skeleton. Although this disease is rare in Japan, it is common in western and southern Europe, and among British migrants in Australia and New Zealand. Bisphosphonates have been widely used for the treatment of Paget's disease of the bone and are...
متن کاملPaget's disease of bone.
Paget's disease is a relatively common bone disease. This review aims to present reasonable treatment recommendations with enough background to understand them. To accomplish this end, some aspects of basic bone cell biology, biochemistry, and pathology are presented, as are speculations about possible causes of this disease. Treatment of Paget's disease will be considered in three sections. Th...
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OBJECTIVE The aim of this guideline was to formulate practice guidelines for the diagnosis and treatment of Paget's disease of the bone. PARTICIPANTS The guideline was developed by an Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer. EVIDENCE This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and...
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OBJECTIVES To assess the efficacy of a single intravenous infusion of pamidronate in Paget's disease of bone. METHODS Fourteen patients with active Paget's disease (raised serum alkaline phosphatase, bone pain or neurological involvement) were treated with a single intravenous infusion of 105 mg pamidronate. Patients were assessed for biochemical and clinical improvement for up to two years f...
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عنوان ژورنال:
- British medical journal
دوره 296 6617 شماره
صفحات -
تاریخ انتشار 1953